I played for years alongside Magic, with some Magic players. Never did the pokemon or yugioh thing, we were all a little more adult I think.
I still have the remnants of a deck, a Hero of the Empire deck using lots of TWT stuff. It sucked, compared to the Klingon Fleet and the Cardassian Capture decks that trounced me in the local qualifier tournament I entered...but it was well-made and I made great use of Q the Referee (I had all my cards "magic bullet" effects memorized hehe).
There are a few scattered playgroups that I sell to around the world...one in Australia, a few in England and Europe. Rarely, but once in a while, some playgroups from the States will buy from me...but most of my sales are to set completionists...people who used to play and now just like to keep the cards.
It's a shame since I'm really impressed with 2E's balance and flexibility. Player interaction is great with the "drawing dilemmas" mechanic and it rewards detailed and attentive play, meaning smart people who pay attention really do get rewarded with the edge.
That said...it's Star Trek, and will always have a stigma attached to it. It's just not Cool except to fellow Trekkies, and even then elitist Trekkers will look down their noses at any CCG, no matter how well-made. They're the kind of collectors who keep their electronic sound-and-light phaser mint-in-box and never once pull the trigger. What a shame